Lai Lab
Electrophysiological Properties of Proprioception-Related Neurons in the Intermediate Thoracolumbar Spinal Cord.
Espinosa F, Pop IV, Lai HC. eNeuro. 2024 Apr 26;11(4):ENEURO.0331-23.2024. *Spinal cord image featured on eNeuro blog*
Structure of long-range direct and indirect spinocerebellar pathways as well as local spinal circuits mediating proprioception.
Pop IV, Espinosa F, Blevins CJ, Okafor PC, Ogujiofor OW, Goyal M, Mona B, Landy MA, Dean KM, Gurumurthy CB, Lai HC. J Neurosci. 2022 Jan 26;42(4):581-600. *Cover Image*
Electrophysiological Properties of Proprioception-Related Neurons in the Intermediate Thoracolumbar Spinal Cord.
Espinosa F, Pop IV, Lai HC. eNeuro. 2024 Apr 26;11(4):ENEURO.0331-23.2024.
Structure of long-range direct and indirect spinocerebellar pathways as well as local spinal circuits mediating proprioception.
Pop IV, Espinosa F, Blevins CJ, Okafor PC, Ogujiofor OW, Goyal M, Mona B, Landy MA, Dean KM, Gurumurthy CB, Lai HC. J Neurosci. 2022 Jan 26;42(4):581-600.
Nociceptor subtypes are born continuously over DRG development.
Landy MA, Goyal M, Lai HC. Dev Bio. 2021. Dev Biol. 2021 Nov;479:91-98.
Loss of Prdm12 during development, but not in mature nociceptors, causes defects in pain sensation.
Landy MA, Goyal M, Casey KM, Liu C, Lai HC. Cell Rep. 2021 Mar 30;34(13):108913.
An Atoh1 CRE knock-in mouse labels motor neurons involved in fine motor control.
Ogujiofor OW, Pop IV, Espinosa F, Durodoye RO, Viacheslavov ML, Jarvis R, Landy MA, Gurumurthy CB, Lai HC. eNeuro. 2021 Feb 1;8(1):ENEURO.0221-20.2021.
Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates.
Faure L, Wang Y, Kastriti ME, Fontanet P, Cheung KKY, Petitpré C, Wu H, Sun LL, Runge K, Croci L, Landy MA, Lai HC, Consalez GG, de Chevigny A, Lallemend F, Adameyko I, Hadjab S. Nat Commun. 2020 Aug 21;11(1):4175.
Comparative transcriptomic analyses of developing melanocortin neurons reveal new regulators for the anorexigenic neuron identity.
Chen X, Wyler SC, Li L, Arnold AG, Wan R, Jia L, Landy MA, Lai HC, Xu P, Liu C. (2020). J Neurosci. 40(16):3165-3177.
PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis.
Bartesaghi L, Wang Y, Fontanet P, Wanderoy S, Berger F, Wu H, Akkuratova N, Bouçanova F, Médard JJ, Petitpré C, Landy MA, Zhang MD, Harrer P, Stendel C, Stucka R, Dusl M, Kastriti ME, Croci L, Lai HC, Consalez GG, Pattyn A, Ernfors P, Senderek J, Adameyko I, Lallemend F, Hadjab S, Chrast R. Cell Rep. 2019 Mar 26;26(13):3484-3492.
Making sense out of spinal cord somatosensory development.
Lai HC, Seal RP, Johnson JE. Development. 2016 Oct 1;143(19):3434-3448. Review.
Origin of a Non-Clarke’s Column Division of the Dorsal Spinocerebellar Tract and the Role of Caudal Proprioceptive Neurons in Motor Function.
Yuengert R, Hori K, Kibodeaux EE, McClellan JX, Morales JE, Huang TP, Neul JL, Lai HC. Cell Rep. 2015 Nov 10;13(6):1258-1271.
Postdoc
Prdm13 mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.
Chang JC, Meredith DM, Mayer PR, Borromeo MD, Lai HC, Ou YH, Johnson JE. Dev Cell. 2013 Apr 29;25(2):182-95.
Transcription factor Sox11 is essential for both embryonic and adult neurogenesis.
Wang Y, Lin L, Lai H, Parada LF, Lei L. Dev Dyn. 2013 Jun;242(6):638-53.
Factors in neurogenesis and neuronal subtype specification.
Lai HC, Meredith DM, Johnson JE Developmental Neuroscience: A Comprehensive Reference, Volume 1, 2013
In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord.
Lai HC, Klisch TJ, Roberts R, Zoghbi HY, Johnson JE. J Neurosci. 2011 Jul 27;31(30):10859-71.
HP1alpha guides neuronal fate by timing E2F-targeted genes silencing during terminal differentiation.
Panteleeva I, Boutillier S, See V, Spiller DG, Rouaux C, Almouzni G, Bailly D, Maison C, Lai HC, Loeffler JP, Boutillier AL EMBO J. 2007 Aug 26 15 3616-28.
The beginning
Structure prediction for the down state of a potassium channel voltage sensor.
Grabe M, Lai HC, Jain M, Jan YN, Jan LY. Nature. 2007 Feb 1;445(7127):550-3. Epub 2006 Dec 24.
The distribution and targeting of neuronal voltage-gated ion channels.
Lai HC, Jan LY. Nat Rev Neurosci. 2006 Jul;7(7):548-62. Review.
The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel.
Lai HC, Grabe M, Jan YN, Jan LY. Neuron. 2005 Aug 4;47(3):395-406.
A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism.
Serber Z, Lai HC, Yang A, Ou HD, Sigal MS, Kelly AE, Darimont BD, Duijf PH, Van Bokhoven H, McKeon F, Dötsch V. Mol Cell Biol. 2002 Dec;22(24):8601-11.
Efficient identification of amino acid types for fast protein backbone assignments.
Ou HD, Lai HC, Serber Z, Dötsch V J. Biomol. NMR 2001 Nov 21 3 269-73.